The Clinical Prognostic Value of Lactylation-Regulated Proteins in Gastric Cancer

= 0.032). In addition, pan-lactylation level was an independent prognostic predictor (HR = 2.06, 95%CI: 1.51-2.80). Four prognostic models were constructed with different advantages, while the RSF model achieved superior training performance (5-year C-index = 0.837), while COX regression demonstrated optimal validation robustness (5-year C-index = 0.624). Pan-lactylation is a novel prognostic biomarker for GC. The lactylation-driven prognostic signature facilitates precise risk stratification in GC patients, providing a framework for personalized therapeutic intervention.