化学
查尔酮
废止
三嗪
键裂
药物化学
立体化学
有机化学
催化作用
作者
Pengzhen Zhong,Cheng Zhang,Yue Li,Chengwu Su,Chen Zhang,Dong Cui
标识
DOI:10.1021/acs.joc.3c01497
摘要
An efficient synthesis of α-(1,3,5-triazinylthio)-ketones from 1,3-dicarbonyl compounds with 1,3,5-triazine-2-thiols has been developed. The reaction proceeds through the C–C bond cleavage and C–S bond reconstruction of 1,3-dicarbonyl compounds, and β-keto esters, β-keto amides, and 1,3-diones were tolerated. In addition, the annulation of 1,3,5-triazine-2-thiols with chalcones has been achieved for the synthesis of thiazolo[3,2-a][1,3,5]triazines. The method occurred in moderate to good yields and tolerated chalcone with a broad functional group.
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