人工细胞
纳米技术
计算机科学
生化工程
人工智能
工程类
化学
材料科学
生物化学
膜
作者
Qianfan Xu,Zeping Zhang,Pauline Po Yee Lui,Liang Lu,Xiaowu Li,Xing Zhang
标识
DOI:10.1016/j.mtbio.2023.100877
摘要
Artificial cells have received much attention in recent years as cell mimics with typical biological functions that can be adapted for therapeutic and diagnostic applications, as well as having an unlimited supply. Although remarkable progress has been made to construct complex multifunctional artificial cells, there are still significant differences between artificial cells and natural cells. It is therefore important to understand the techniques and challenges for the fabrication of artificial cells and their applications for further technological advancement. The key concepts of top-down and bottom-up methods for preparing artificial cells are summarized, and the advantages and disadvantages of the bottom-up methods are compared and critically discussed in this review. Potential applications of artificial cells as drug carriers (microcapsules), as signaling regulators for coordinating cellular communication and as bioreactors for biomolecule fabrication, are further discussed. The challenges and future trends for the development of artificial cells simulating the real activities of natural cells are finally described.
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