化学
透明质酸
CD44细胞
抗体
免疫疗法
癌症研究
细胞毒性
鼠李糖
癌症免疫疗法
环糊精
癌症
抗体依赖性细胞介导的细胞毒性
肽
癌细胞
生物化学
细胞
免疫学
体外
内科学
医学
半乳糖
遗传学
生物
作者
Lei Zheng,Yanchun Li,Han Lin,Haifei Hong,Jie Shi,Zhifang Zhou,Zhimeng Wu
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-05-15
摘要
Abstract A new generation of multivalent antibody-recruiting molecules (ARMs) with dual-targeting tumor-binding termini (TBT), including hyaluronic acid targeting CD44 and nanobody 7D12 or peptide GE11 targeting EGFR, was constructed for cancer immunotherapy. The 7D12 or GE11 were assembled onto β-cyclodextrin-grafted hyaluronic acid (HACD) with multivalent rhamnose via host-guest interaction to form macromolecule complexes. The immunological studies proved that these complexes had dual-targetability on CD44 and EGFR and the rhamnose on HACD could recruit anti-Rha antibodies to mediate cytotoxicity against the targeted tumor cells. This bispecific ARM strategy provides a platform for cancer immunotherapy.
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