Construction of chitosan-based supramolecular biofilm material for wound dressing based on natural deep eutectic solvents

Bacterial infection is still one of the main problems observed in the clinical process of wound healing, so the development of new multifunctional biocompatible materials is an urgent clinical need. A kind of supramolecular biofilm crosslinked by hydrogen bond between natural deep eutectic solvent and chitosan was studied and successfully prepared to reduce bacterial infection. Its killing rates of Staphylococcus aureus and Escherichia coli can reach 98.86 % ± 1.90 % and 99.69 % ± 0.53 %, and it can be degraded in both soil and water, showing excellent biocompatibility and biodegradability. In addition, the supramolecular biofilm material also has the UV barrier property, which can effectively avoid the secondary injury of UV to the wound. Interestingly, the cross-linking effect of hydrogen bond makes the biofilm have a more compact structure and rough surface, and gives the biofilm strong tensile properties. Overall, owing to these unique advantages, NADES-CS supramolecular biofilm has great potential for medical applications, laying the foundation for the realization of sustainable polysaccharide materials.