Distinct genetic risk loci between biopsy-proven renal and non-renal lupus: a 10-year longitudinal cohort

Different subphenotypes of SLE are predisposed by distinct genetic risk loci, which can only be identified in clearly subphenotyped cohorts with sufficient longitudinal data. We identified unique genetic risk loci enriched among patients with biopsy-proven LN, and postulate that individual subphenotypes may have varying genetic predisposition.