Mesoporous Nanoplatform That Efficiently Delivers DOX as an H2O2 Generator to Trigger Mutual Amplification of Cuproptosis and Chemodynamic Therapy

via a Fenton-like reaction. This accelerates the transformation of the oxidation state of copper ions, maximizing the dihydrolipoamide S-acetyltransferase(DLAT)-aggregation induced cuproptosis effects, while GSH is greatly depleted to sensitize the CDT effect. The efficacy of the NSs is evaluated both in vitro and in vivo, demonstrating overall superior anti-tumor efficacy originating from the mutually amplified cuproptosis/CDT effects and the chemotherapy effects of DOX.