废止
化学
组合化学
催化作用
分子
钴
基质(水族馆)
乙二醛
功能群
有机化学
海洋学
地质学
聚合物
作者
Huiru Yang,Zheyao Hu,Xin-Chang Li,Lin Wu,Xun‐Xiang Guo
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-09
卷期号:24 (45): 8392-8396
被引量:8
标识
DOI:10.1021/acs.orglett.2c03465
摘要
A novel methodology for the annulation of terminal alkynes and o-phenylenediamines by using a combination of a cobalt catalyst and oxygen as a terminal oxidant is reported. This method shows wide substrate scope and good functional group tolerance and provides a wide range of quinoxalines in good to high yields. The method is demonstrated by its gram-scale and broad potential applications. Furthermore, this protocol serves as a powerful tool for the late-stage functionalization of various complex bioactive molecules and drugs to provide a new class of molecules containing two distinct bioactive molecules directly linked. Detailed mechanistic studies reveal that the current reaction goes through a novel mechanism different from the previously reported glyoxal mechanism.
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