神经可塑性
痛觉过敏
慢性疼痛
医学
神经科学
幻觉痛
伤害
痛觉超敏
病态的
中枢神经系统
心理学
内科学
精神科
受体
截肢
作者
Masoumeh Kourosh-Arami,Alireza Komaki
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2023-12-01
卷期号:22 (10): 1484-1492
被引量:2
标识
DOI:10.2174/1871527322666221102141002
摘要
Considerable functional and structural alterations, or plasticity, in the central nervous system (CNS) are accompanied by numerous chronic pain syndromes. Sensitization of the peripheral (primary hyperalgesia) or central (secondary hyperalgesia) nervous system as unhelpful neuroplasticity may result in stimulus-induced pain (hyperalgesia and allodynia). Furthermore, nociception induces extensive plasticity in the peripheral and central neural systems in pathological disease states. Diseaseinduced plasticity at both structural and functional levels is evident as alterations in different molecules, synapses, cellular function and network activity. In the present article, we review plasticityinduced pain and pain-induced plasticity. Moreover, we will review the pain matrix. Furthermore, we will focus on recent developments of CNS alterations in long-lasting pain in some clinical entities encountered in rehabilitation. These clinical entities comprise nonspecific low back pain, complex regional pain syndrome, postamputation phantom pain, fibromyalgia, and chronic pain after spinal cord injury. Moreover, we will review the clinical treatment for the inhibition of pathological pain.
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