姜黄素
自噬
活性氧
氧化应激
细胞凋亡
化学
内质网
急性肾损伤
药理学
未折叠蛋白反应
肾毒性
顺铂
癌症研究
细胞生物学
毒性
医学
生物化学
化疗
生物
内科学
有机化学
作者
Tianyu Lan,Honglei Guo,Xin Lü,Kedui Geng,Lin Wu,Yongjun Luo,Jian Zhu,Xiangchun Shen,Qianqian Guo,Shuizhu Wu
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2022-11-16
卷期号:23 (12): 5253-5266
被引量:4
标识
DOI:10.1021/acs.biomac.2c01083
摘要
Acute kidney injury (AKI) has been a global public health concern leading to high patient morbidity and mortality in the world. Nanotechnology-mediated antioxidative therapy has facilitated the treatment of AKI. Herein, a hierarchical curcumin-loaded nanodrug delivery system (NPS@Cur) was fabricated for antioxidant therapy to ameliorate AKI. The nanoplatform could respond to subacidic and reactive oxygen species (ROS) microenvironments. The subacidic microenvironment led to a smaller size (from 140.9 to 99.36 nm) and positive charge (from -4.9 to 12.6 mV), contributing to the high accumulation of nanoparticles. An excessive ROS microenvironment led to nanoparticle degradation and drug release. In vitro assays showed that NPS@Cur could scavenge excessive ROS and relieve oxidative stress in H2O2-induced HK-2 cells through reduced apoptosis, activated autophagy, and decreased endoplasmic reticulum stress. Results from cisplatin-induced AKI models revealed that NPS@Cur could effectively alleviate mitochondria injury and protect kidneys via antioxidative protection, activated autophagy, decreased endoplasmic reticulum stress, and reduced apoptosis. NPS@Cur showed excellent biocompatibility and low toxicity to primary tissues in mice. These results revealed that NPS@Cur may be a potential therapeutic strategy for efficiently treating cisplatin or other cause-induced AKI.
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