清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Novel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseases

药店 中国 医学 传统医学 家庭医学 政治学 法学
作者
Changyu Ren,Jiao Liu,Shiyun Pu,Houfeng Zhou,Jinqi Li,Jifa Zhang
出处
期刊:Future Medicinal Chemistry [Future Science Ltd]
卷期号:15 (5): 395-397
标识
DOI:10.4155/fmc-2023-0035
摘要

Future Medicinal ChemistryVol. 15, No. 5 EditorialNovel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseasesChangyu Ren, Jiao Liu, Shiyun Pu, Houfeng Zhou, Jinqi Li & Jifa ZhangChangyu RenDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Jiao LiuDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Shiyun PuDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Houfeng ZhouDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Jinqi Li*Author for correspondence: E-mail Address: lijinqi2002@126.comDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, ChinaSearch for more papers by this author & Jifa Zhang**Author for correspondence: E-mail Address: zjf298257@163.comDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaJoint Research Institution of Altitude Health, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, ChinaSearch for more papers by this authorPublished Online:31 Mar 2023https://doi.org/10.4155/fmc-2023-0035AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: neurodegenerative diseasesnovel strategyproteolysis targeting chimerastargeted protein degradationReferences1. Kumar D, Md Ashraf G, Bilgrami AL, Imtaiyaz Hassan M. Emerging therapeutic developments in neurodegenerative diseases: a clinical investigation. Drug Discov. Today. 27(10), 103305 (2022).Crossref, Medline, CAS, Google Scholar2. Soto C, Pritzkow S. Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. Nat. Neurosci. 21(10), 1332–1340 (2018).Crossref, Medline, CAS, Google Scholar3. Tomoshige S, Ishikawa M. PROTACs and other chemical protein degradation technologies for the treatment of neurodegenerative disorders. Angew. Chem. Int. Ed. 60(7), 3346–3354 (2021).Crossref, Medline, CAS, Google Scholar4. Zalewska T, Pawelec P, Ziabska K, Ziemka-Nalecz M. Sexual dimorphism in neurodegenerative diseases and in brain ischemia. Biomolecules. 13(1), 26 (2022).Crossref, Medline, Google Scholar5. Balestrino R, Schapira AHV. Parkinson disease. Eur. J. Neurol. 27(1), 27–42 (2020).Crossref, Medline, CAS, Google Scholar6. Rana T, Behl T, Sehgal A et al. Exploring the role of autophagy dysfunction in neurodegenerative disorders. Mol. Neurobiol. 58(10), 4886–4905 (2021).Crossref, Medline, CAS, Google Scholar7. Araldi RP, D'Amelio F, Vigerelli H et al. Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology. Cells. 9(12), 2663 (2020).Crossref, Medline, CAS, Google Scholar8. Setten RL, Rossi JJ, Han S. The current state and future directions of RNAi-based therapeutics. Nat. Rev. Drug Discov. 18(6), 421–446 (2019).Crossref, Medline, CAS, Google Scholar9. Katti A, Diaz BJ, Caragine CM et al. CRISPR in cancer biology and therapy. Nat. Rev. Cancer. 22(5), 259–279 (2022).Crossref, Medline, CAS, Google Scholar10. Kargbo RB. PROTAC compounds targeting α-synuclein protein for treating neurogenerative disorders: Alzheimer's and Parkinson's diseases. ACS Med. Chem. Lett. 11(6), 1086–1087 (2020).Crossref, Medline, CAS, Google Scholar11. Chu T-T, Gao N, Li Q-Q et al. Specific knockdown of endogenous tau protein by peptide-directed ubiquitin-proteasome degradation. Cell Chem. Biol. 23(4), 453–461 (2016).Crossref, Medline, CAS, Google Scholar12. Fang Y, Wang J, Zhao M et al. Progress and challenges in targeted protein degradation for neurodegenerative disease therapy. J. Med. Chem. 65(17), 11454–11477 (2022).Crossref, Medline, CAS, Google Scholar13. Li H, Dong J, Cai M et al. Protein degradation technology: a strategic paradigm shift in drug discovery. J. Hematol. Oncol. 14(1), 138 (2021).Crossref, Medline, CAS, Google Scholar14. Naito M, Ohoka N, Shibata N. SNIPERs – hijacking IAP activity to induce protein degradation. Drug Discov. Today Technol. 31, 35–42 (2019).Crossref, Medline, Google Scholar15. Hirai K, Yamashita H, Tomoshige S et al. Conversion of a PROTAC mutant Huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties. ACS Med. Chem. Lett. 13(3), 396–402 (2022).Crossref, Medline, CAS, Google Scholar16. Takahashi D, Arimoto H. Targeting selective autophagy by AUTAC degraders. Autophagy. 16(4), 765–766 (2020).Crossref, Medline, CAS, Google Scholar17. Ding Y, Fei Y, Lu B. Emerging new concepts of degrader technologies. Trends Pharmacol. Sci. 41(7), 464–474 (2020).Crossref, Medline, CAS, Google Scholar18. Zhang J, Huang Y, Liu W et al. Chaperone-mediated autophagy targeting chimeras (CMATAC) for the degradation of ERα in breast cancer. BIOCELL. 44(4), 591–595 (2020).Crossref, CAS, Google Scholar19. Dey SK, Jaffrey SR. RIBOTACs: small molecules target RNA for degradation. Cell Chem. Biol. 26(8), 1047–1049 (2019).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 5 STAY CONNECTED Metrics Downloaded 55 times History Received 5 February 2023 Accepted 7 February 2023 Published online 31 March 2023 Published in print March 2023 Information© 2023 Newlands PressKeywordsneurodegenerative diseasesnovel strategyproteolysis targeting chimerastargeted protein degradationFinancial & competing interests disclosureThe authors thank the Natural Science Foundation of Sichuan (No. 2023NSFSC1695), Health Commission of Sichuan Province (No. 21PJ149) and Xinglin Foundation of Chengdu University of TCM (No. YYZX2021043). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the article apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lauren完成签到 ,获得积分10
6秒前
YWY应助ling_lz采纳,获得10
10秒前
LeoBigman完成签到 ,获得积分10
17秒前
白昼完成签到 ,获得积分10
18秒前
Tong完成签到,获得积分0
19秒前
Liu完成签到 ,获得积分10
20秒前
8R60d8应助科研通管家采纳,获得10
20秒前
朴实的小萱完成签到 ,获得积分10
31秒前
AllRightReserved完成签到 ,获得积分10
1分钟前
yang完成签到 ,获得积分0
1分钟前
沉醉的中国钵完成签到 ,获得积分10
1分钟前
8R60d8应助科研通管家采纳,获得10
2分钟前
8R60d8应助科研通管家采纳,获得10
2分钟前
8R60d8应助科研通管家采纳,获得10
2分钟前
轻语完成签到 ,获得积分10
2分钟前
Lillianzhu1完成签到,获得积分10
2分钟前
小白完成签到 ,获得积分10
2分钟前
jeronimo完成签到,获得积分10
2分钟前
2分钟前
spinon完成签到,获得积分10
2分钟前
WenJun完成签到,获得积分10
3分钟前
洁净的幼珊完成签到,获得积分10
3分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
8R60d8应助科研通管家采纳,获得10
4分钟前
胡萝卜完成签到,获得积分10
4分钟前
激动的似狮完成签到,获得积分0
4分钟前
gzhy完成签到,获得积分10
4分钟前
xl_c完成签到 ,获得积分10
4分钟前
androabo完成签到,获得积分10
5分钟前
铜豌豆完成签到 ,获得积分10
5分钟前
jlwang完成签到,获得积分10
6分钟前
hebhm完成签到,获得积分10
6分钟前
8R60d8应助科研通管家采纳,获得20
6分钟前
8R60d8应助科研通管家采纳,获得10
6分钟前
8R60d8应助科研通管家采纳,获得10
6分钟前
8R60d8应助科研通管家采纳,获得10
6分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
晶种分解过程与铝酸钠溶液混合强度关系的探讨 8888
Les Mantodea de Guyane Insecta, Polyneoptera 2000
The Organometallic Chemistry of the Transition Metals 800
Leading Academic-Practice Partnerships in Nursing and Healthcare: A Paradigm for Change 800
Signals, Systems, and Signal Processing 610
The formation of Australian attitudes towards China, 1918-1941 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6418906
求助须知:如何正确求助?哪些是违规求助? 8238489
关于积分的说明 17502275
捐赠科研通 5471837
什么是DOI,文献DOI怎么找? 2890976
邀请新用户注册赠送积分活动 1867703
关于科研通互助平台的介绍 1704741