Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect

In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL^-1), good selectivity, and wide linear range (0.003-10 ng mL^-1). In addition, it can be directly applied for the determination of CEA in human serum.