化学
背景(考古学)
反应性(心理学)
组合化学
铂金
癌症治疗
纳米技术
配位复合体
钌
癌症
金属
有机化学
医学
材料科学
内科学
替代医学
催化作用
病理
古生物学
生物
作者
Peshang Khdir Omer,Nazk Mohammed Aziz,Rebaz Anwar Omer
出处
期刊:Reviews in Inorganic Chemistry
[De Gruyter]
日期:2024-08-07
卷期号:44 (4): 699-710
被引量:3
标识
DOI:10.1515/revic-2024-0030
摘要
Abstract Throughout history, metal-based coordination compounds have been used for medical purposes, including the treatment of various illnesses like cancer. Since the discovery of cisplatin in 1965, many other metal coordinating complexes have been developed and evaluated, involving metals such as platinum, iron, zinc, ruthenium, gold, silver, titanium, and copper. The goal behind these efforts is to create effective and safe medications. At the moment, there are a lot of studies talking about the use of cytostatic metal complexes, mainly on promising platinum- and non-platinum-based drugs in both preclinical and clinical trials. However, there is a lack of recent comprehensive studies that cover both the chemical and biological aspects of metal-based coordinating molecules in the context of cancer therapy. This review aims to provide a thorough analysis of the coordination chemistry of existing and innovative cytostatic substances. It will include a description of their design and synthesis, as well as a summary of the biochemical reactivity and physicochemical features of potential metal-containing complexes.
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