WCN23-0284 GASDERMIN D-DEFICIENT MICE ARE HYPERSENSITIVE TO AKI

Within the last decade, it has been established that necrotic rather than apoptotic cell death critically mediates acute tubular necrosis in AKI. While the involvement of necroptosis and ferroptosis has been established, the role of pyroptosis, the third major form of necrosis, remains unclear in AKI. This form of regulated necrosis requires proteolytic activation of members of the gasdermin family and is considered highly immunogenic. Thus, we aimed to investigate the role of pyroptosis and its mechanism of action in AKI.