细胞毒性
植物化学
异黄酮素
黄酮类
传统医学
化学
IC50型
立体化学
生物化学
体外
色谱法
医学
作者
Pornphimon Meesakul,Virayu Suthiphasilp,Passakorn Teerapongpisan,Narawadee Rujanapun,Boonyanoot Chaiyosang,Sarawut Tontapha,Piyaporn Phukhatmuen,Tharakorn Maneerat,Rawiwan Charoensup,Thidarat Duangyod,Brian O. Patrick,Raymond J. Andersen,Surat Laphookhieo
标识
DOI:10.1016/j.phytochem.2022.113440
摘要
Phytochemical investigations of the leaf and pod extracts of Millettia brandisiana Kurz led to the isolation and identification of four previously undescribed rotenoids, (–)-(6aS,12aS)-millettiabrandisins A–C and (–)-(6aS,12aS)-6-deoxyclitoriacetal, two previously undescribed isoflavones, millettiabrandisins D and E, and 20 known compounds. The structures of previously undescribed compounds were determined on the basis of NMR and MS data. The absolute configurations of (–)-(6aS,12aS)-millettiabrandisins A–C were determined from the comparison of their experimental and calculated ECD spectra. (–)-(6aR,12aR)-12a-Hydroxy-α-toxicarol was also confirmed by X-ray crystallographic data. Some isolated compounds were evaluated for their cytotoxicity against three cancer cell lines, including lung cancer (A549), colorectal cancer (SW480), and leukemic cells (K562). Of these, α-toxicarol displayed the best cytotoxicity against lung cancer (A549) and leukemic cells (K562) with the IC50 values of 104.4 and 67.5 μM, respectively. 6″,6″-Dimethylchromene-[2″,3″:7,8]-flavone showed the highest cytotoxicity against colorectal cancer (SW480) with an IC50 value of 97.2 μM.
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