基因组
生物
人类基因组
转基因
基因组工程
插入(复合材料)
计算生物学
遗传学
基因组编辑
外源DNA
功能(生物学)
基因
工程类
机械工程
作者
Michel Sadelain,Eirini P. Papapetrou,Frederic D. Bushman
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2011-12-01
卷期号:12 (1): 51-58
被引量:365
摘要
Interactions between newly integrated DNA and the host genome limit the reliability and safety of transgene integration for therapeutic cell engineering and other applications. Although targeted gene delivery has made considerable progress, the question of where to insert foreign sequences in the human genome to maximize safety and efficacy has received little attention. In this Opinion article, we discuss 'genomic safe harbours' - chromosomal locations where therapeutic transgenes can integrate and function in a predictable manner without perturbing endogenous gene activity and promoting cancer.
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