糖胺聚糖
伤口愈合
肝素
医学
硫酸皮肤素
抗凝剂
糖尿病
糖尿病足
碘脲酸
氨基葡萄糖
炎症
血管生成
蜗牛
硫酸乙酰肝素
药理学
免疫学
化学
外科
内科学
生物化学
内分泌学
生物
解剖
生态学
作者
Yuebo Wu,Zhipeng Zhou,Luo Li,Maixian Tao,X.C. Chang,Lian Yang,Xingyong Huang,Lin Hu,Mingyi Wu
标识
DOI:10.1016/j.carbpol.2020.116682
摘要
Diabetic foot ulcer (DFU) is a common high-risk complication in patients with diabetes mellitus, but current drugs and therapies in management of this disease cannot meet the urgent clinical needs. In this study, a snail glycosaminoglycan (SGAG) from the cultured China white jade snail was purified and structurally clarified. This snail glycosaminoglycan is a regular sulfated polysaccharide, composed of iduronic acid (IdoA) and N-acetyl-glucosamine (GlcNAc) with the repeating sequence of →4)-α-GlcNAc (1→4)-α-IdoA2S (1→. The biological assays showed that SGAG had no anticoagulant activity for lacking specific heparin pentasaccharide sequence. The pharmacological experiments suggested that SGAG markedly accelerated the healing of full-thickness wounds in diabetic mice skin. Histologic and immunohistochemical analysis revealed that SGAG treatment alleviated the inflammation and dermal edema, and promoted angiogenesis. This is the first report applying the snail glycosaminoglycan to favor diabetic wound healing.
科研通智能强力驱动
Strongly Powered by AbleSci AI