化学
硫醇
肽
肽合成
放射化学
组合化学
立体化学
有机化学
生物化学
作者
Huanglan Zhuang,Zhide Guo,Rongqiang Zhuang,Xianzhong Zhang
摘要
Two 18 F-radiolabeled organofluorophosphine fluorides ([18 F]4 and [18 F]7) for chemoselective thiol-conjugation were designed and synthesized via 18 F-19 F isotopic exchange reaction. This simple and rapid radiofluorination produced both 18 F-radiolabeled fluorides in excellent radiochemical yields (>94%) and radiochemical purity. The optimal reaction conditions are 0.05-mg substrate, 0.69 mg of potassium carbonate, and dried [18 F]F- were mixed in 100-μl anhydrous acetonitrile at room temperature for 5 min. Both of [18 F]4 and [18 F]7 showed specificity for thiol-conjugation with cysteine and have been used in the radiosynthesis of c (RGDfC). The [18 F]7 with an adamantanyl-hindered substituent displayed superior in vitro and in vivo stability.
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