胶质瘤
免疫疗法
医学
免疫系统
CD8型
免疫
归巢(生物学)
溶瘤病毒
趋化因子
癌症研究
免疫刺激剂
免疫学
生物
生态学
作者
Jing Zhang,Chen Chen,Anning Li,Weiqiang Jing,Ping Sun,Xingyi Huang,Yingchao Liu,Shengchang Zhang,Wei Du,Rui Zhang,Ying Liu,Aihua Gong,Jibiao Wu,Xinyi Jiang
标识
DOI:10.1038/s41565-020-00843-7
摘要
Immunotherapies have revolutionized intervention strategies for many primary cancers, but have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of the most lethal malignant cerebral tumours. Here we present an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, which mitigates its relapse. The hydrogel comprises a tumour-homing immune nanoregulator, which induces immunogenic cell death and suppression of indoleamine 2,3-dioxygenase-1, and chemotactic CXC chemokine ligand 10, for a sustained T-cell infiltration. When delivered in the resected tumour cavity, the hydrogel system mimics a ‘hot’ tumour-immunity niche for attacking residual tumour cells and significantly suppresses postoperative GBM recurrence. Our work provides an alternative strategy for conferring effective tumoricidal immunity in GBM patients, which may have a broad impact in the immunotherapy of ‘cold’ tumours after surgical intervention.
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