微乳液
壳聚糖
动态光散射
Zeta电位
姜黄素
肺表面活性物质
药物输送
化学
聚合物
核化学
化学工程
电导率
材料科学
乳状液
纳米技术
纳米颗粒
有机化学
物理化学
工程类
生物化学
作者
Daniela Díaz-Zepeda,René D. Peralta,Bertha Puente-Urbina,Gladis Yakeline Cortez-Mazatán,H. Iván Meléndez‐Ortiz
标识
DOI:10.1080/00914037.2020.1857761
摘要
Oil-in-water microemulsions (o/w MEs) were coated with chitosan to obtain new curcumin delivery systems. First, ternary phase diagrams were constructed using mixtures of Tween 20, Tween 80, ethanol, and monopropyleneglycol (MPG) to determine the macroscopic phase region of MEs and their capacity to incorporate clove oil. Particularly, MEs with size less than 20 nm could be formed using low amount of the surfactant Tween 20. The prepared MEs were subjected to diverse stability tests and characterized by dynamic light scattering (DLS), zeta potential (Z potential), conductivity, pH, and transmission electron microscopy (TEM). Stable, spherical uncoated and polymer-coated MEs were obtained with low droplet size (Dp), <50 nm, for the water/Tween 20/clove oil/ and water/Tween80/MPG/clove oil systems using a chitosan solution of 1 mg/mL. For all polymer-coated MEs, an increase of Z potential (17–54 mV) was observed due to the presence of chitosan. The loading with curcumin did not affect the Dp of MEs (e.g., for ME with Tween 20, Dp unloaded 12.35 ± 1.86 nm and Dp loaded 11.13 ± 0.32 nm) but Z potential and conductivity values were increased (typically for coated ME prepared with Tween 20 17.00 ± 0.36 mV ≤Z potential ≤41.5 mV, 162.20 ± 8.95 μS/cm ≤ conductivity ≤183.8 ± 0.56 μS/cm). Drug delivery studies for the chitosan-coated MEs were carried out at different pH (7.4, 6.5, and 5.8). The release of curcumin from the chitosan-coated MEs, formed with Tween 20, showed a dependence of the pH with a maximum release at the acidic pH of 5.8 (58%). The release of curcumin from all MEs was best described by the Korsmeyer- Peppas model with a Fickian transport mechanism.
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