药代动力学
万古霉素
肾脏替代疗法
加药
色谱法
尿
基质(化学分析)
化学
治疗药物监测
医学
药理学
重症监护医学
内科学
金黄色葡萄球菌
细菌
生物
遗传学
作者
Suzanne L. Parker,Yarmarly C. Guerra Valero,Jenny Lisette Ordóñez Mejia,Claire Roger,Jeffrey Lipman,Jason A. Roberts,Steven C. Wallis
出处
期刊:Bioanalysis
[Newlands Press Ltd]
日期:2017-06-01
卷期号:9 (12): 911-924
被引量:17
标识
DOI:10.4155/bio-2017-0019
摘要
Aim: Critical illness and medical interventions, such as renal replacement therapy, can cause changes to vancomycin pharmacokinetics and lead to suboptimal dosing. To comprehensively characterize vancomycin pharmacokinetic a method must measure vancomycin in a range of clinical matrices. Results: A LC–MS/MS method was developed using hydrophilic interaction liquid chromatography and microsample volumes, where possible. For all matrices, the linear concentration range was 1–100 μg/ml, interassay accuracy and precision was within 15%, and recovery above 80%. No matrix effects were observed. Calibration equivalence may be applied for some matrix combinations. Conclusion: A method for the analysis of vancomycin in plasma (total, unbound), urine and renal replacement therapy effluent, suitable for use in any patient pharmacokinetic study, has been developed and validated.
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