Microbe-derived aromatic polyketides toward MRSA infection: current advances and perspectives

) from microbial sources, and summarizes their structure-activity relationships, additional bioactivities, and reported antibacterial mechanisms. Meanwhile, the clinical utilization status, limitations, and ongoing challenges associated with existing anti-MRSA aromatic polyketide antibiotics were assessed, alongside valuable perspectives on the potential advancement of aromatic polyketide derivatives. Additionally, the review provides further insights into drug innovation and future trends in medicinal research regarding the rational development of anti-MRSA aromatic polyketide drugs, offering a valuable reference for future research and pharmaceutical development.