静息状态功能磁共振成像
脑岛
意识
辅助电机区
大脑活动与冥想
心理学
意识水平
神经科学
持续植物状态
听力学
平衡(能力)
功能磁共振成像
意识障碍
最小意识状态
医学
脑电图
发展心理学
作者
Jianghong He,Yi Yang,Yi Zhang,Si-You Qiu,Zhenyu Zhou,Yuanyuan Dang,Yiwu Dai,Yijun Liu,Ran Xu
摘要
Resting‐state functional MRI (fMRI) has emerged as a valuable tool to characterize the complex states encompassing disorders of consciousness (DOC). Awareness appears to comprise two coexistent, anticorrelated components named the external and internal awareness networks. The present study hypothesizes that DOC interrupts the balance between the internal and external awareness networks. To gain more understanding of this phenomenon, the present study analyzed resting‐state fMRI data from 12 patients with DOC versus 12 healthy age‐matched controls. The data were explored using independent component analysis and amplitude of low‐frequency fluctuation (ALFF) analysis. The results indicated that DOC deactivated midline areas associated with internal awareness. In addition, external awareness was strengthened in DOC because of increased activation in the insula, lingual gyrus, paracentral and supplementary motor area. The activity patterns suggested strengthened external awareness against weakened internal awareness in DOC. In particular, increased activity found in the insula, lingual gyrus, paracentral and supplementary motor area of patients with DOC implied possible involvement of augmented visuo‐motor modulation in these patients. DOC is probably related to hyperactive external awareness opposing hypoactive internal awareness. This unique pattern of brain activity may potentially be a prognostic marker for DOC. Copyright © 2014 John Wiley & Sons, Ltd.
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