游离脂肪酸受体1
葡萄糖稳态
脂肪酸
受体
分泌物
平衡
胰岛素
游离脂肪酸受体
生物
内分泌学
生物化学
胰岛素抵抗
多不饱和脂肪酸
兴奋剂
作者
Arturo Mancini,Vincent Poitout
标识
DOI:10.1016/j.tem.2013.03.003
摘要
Glucose homeostasis requires the highly coordinated regulation of insulin secretion by pancreatic β cells. This is primarily mediated by glucose itself, but other nutrients, including free fatty acids (FFAs), potentiate the insulinotropic capacity of glucose. A decade ago, the seven-transmembrane domain receptor (7TMR) GPR40 was demonstrated to be predominantly expressed in β cells and activated by long-chain FFAs. This discovery added a new dimension to our understanding of FFA-mediated control of glucose homeostasis. Furthermore, GPR40 has drawn considerable interest as a novel therapeutic target to enhance insulin secretion in type 2 diabetes. However, our understanding of the biology of GPR40 remains incomplete and its physiological role controversial. Here we summarize the current state of knowledge and emerging concepts regarding the role of GPR40 in regulating glucose homeostasis.
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