生物
免疫球蛋白超家族
基因
T细胞
主要组织相容性复合体
T细胞受体
细胞毒性T细胞
遗传学
跨膜蛋白
抗原
分子生物学
受体
免疫系统
体外
作者
Lynn M. Boyden,Julia M. Lewis,Susannah D. Barbee,Anna Bas,Michael Girardi,Adrian Hayday,Robert E. Tigelaar,Richard P. Lifton
出处
期刊:Nature Genetics
[Springer Nature]
日期:2008-04-13
卷期号:40 (5): 656-662
被引量:262
摘要
B cells, alphabeta T cells and gammadelta T cells are conserved lymphocyte subtypes encoding their antigen receptors from somatically rearranged genes. alphabeta T cells undergo positive selection in the thymus by engagement of their T cell receptors (TCRs) with self-peptides presented by major histocompatibility complex molecules. The molecules that select gammadelta T cells are unknown. Vgamma5+Vdelta1+ cells comprise 90% of mouse epidermal gammadelta T cells. By mapping and genetic complementation using a strain showing loss of Vgamma5+Vdelta1+ cells due to a failure of thymic selection, we show that this defect is caused by mutation in Skint1, a newly identified gene expressed in thymus and skin that encodes a protein with immunoglobulin-like and transmembrane domains. Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes. These findings define a new family of proteins mediating key epithelial-immune interactions.
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