骨骼肌
过氧化物酶体增殖物激活受体
内分泌学
内科学
调节器
胰岛素抵抗
调解人
生物
过氧化物酶体
受体
脂质代谢
生物化学
胰岛素
医学
基因
作者
Ewa Ehrenborg,Anna Krook
出处
期刊:Pharmacological Reviews
[American Society for Pharmacology & Experimental Therapeutics]
日期:2009-09-01
卷期号:61 (3): 373-393
被引量:195
标识
DOI:10.1124/pr.109.001560
摘要
Agonists directed against the α and γ isoforms of the peroxisome proliferator-activated receptors (PPARs) have become important for the respective treatment of hypertriglyceridemia and insulin resistance associated with metabolic disease. PPARδ is the least well characterized of the three PPAR isoforms. Skeletal muscle insulin resistance is a primary risk factor for the development of type 2 diabetes. There is increasing evidence that PPARδ is an important regulator of skeletal muscle metabolism, in particular, muscle lipid oxidation, highlighting the potential utility of this isoform as a drug target. In addition, PPARδ seems to be a key regulator of skeletal muscle fiber type and a possible mediator of the adaptations noted in skeletal muscle in response to exercise. In this review we summarize the current status regarding the regulation, and the metabolic effects, of PPARδ in skeletal muscle.
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