Linear free energy relationship and deuterium kinetic isotope effect observed on phospho and thiophosphoryl transfer reactions in some organophosphorous compounds

Tetracoordinated organophosphorous compounds were synthesized, characterized and nucleophilic substitution reaction were investigated by varying substituents around phosphorous centre or in nucleophile considering its utility in biological and environmental system.The reactivity is expressed in terms of second-order rate constant, k 2 and measured conductometrically.Linear Free Energy Relationship (LFER) tools mainly Hammett (), Brönsted () LFER coefficients and deuterium kinetic isotope effects (KIEs) being determined for the pyridinolysis of 4 -chlorophenyl 4 -methoxy phenyl chlorophosphate, 1 in acetonitrile at 5.0 o C. The experimental data's were compared with those of structurally similar organophosphorous compounds reported earlier in quest for the mechanistic information.Nice linear correlation being found for Hammett (logk 2 vs  x ), having negative value of the  X = 5.85 and Brönsted (logk 2 vs pK a(x) ) plots having large positive value for  X = 1.18 for 1 can be interpreted as S N 2 process with greater extent of bond formation in transition state (TS) of 1.The observed k H /k D values of 1 is 1.00 ± 0.05 and net KIE, 1.32 suggests the primary KIE and indicates frontside nucleophilic attack through the partial deprotonation of pyridine occurs by the hydrogen bonding in the rate-determining step.