DNA去甲基化
DNA甲基化
重编程
表观遗传学
生物
表观遗传学
5-羟甲基胞嘧啶
体育锻炼的表观遗传学
遗传学
DNA
基因组印记
细胞
基因
基因表达
摘要
DNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Compared with other epigenetic modifications, DNA methylation is thought to be relatively stable. Despite its role in long-term silencing, DNA methylation is more dynamic than originally thought as active DNA demethylation has been observed during specific stages of development. In the past decade, many enzymes have been proposed to carry out active DNA demethylation and growing evidence suggests that, depending on the context, this process may be achieved by multiple mechanisms. Insight into how DNA methylation is dynamically regulated will broaden our understanding of epigenetic regulation and have great implications in somatic cell reprogramming and regenerative medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI