医学遗传学
生物
外显子组测序
遗传学
人口
基因组学
群体遗传学
致病性
外显子组
基因
医学
基因组
突变
环境卫生
微生物学
作者
Taghrid Aloraini,Lamia Alsubaie,Sarah Alasker,Abdulrahman Al Muitiri,Abdulrahman Alswaid,Wafaa Eyiad,Fuad Al Mutairi,Farouq Ababneh,Majid Alfadhel,Ahmed Alfares
摘要
Secondary findings (SF) are defined as genetic conditions discovered unintentionally during an evaluation of raw data for another disease. We aimed to identify the rate of secondary genetic findings in the Saudi population in the 59 genes of the American College of Medical Genetics and Genomics (ACMG) list. In our study, the raw data of 1254 individuals, generated from exome sequencing for clinical purposes, were studied. Variants detected in the 59 genes on the ACMG list of secondary findings were investigated. Pathogenicity classifications were assigned to those variants based on the ACMG scoring system. We identified 2409 variants in the 59 gene list, 45 variants were classified as pathogenic/likely pathogenic variants according to the ACMG classification. The LDLR gene had the greatest number of pathogenic/likely pathogenic variants 12%. Cardiovascular genetic diseases had the highest frequency of disorders detected as secondary findings. In this study, the overall rate of positive cases identified with secondary findings in the Saudi population was 8%. The different in our current study and the previous studies in Saudi Arabia can be explained by the differences between the sequencing method, the criteria used for variant classification, the availability of newer evidence at the time of the publication, and the fact that we identified Saudi novel variants never reported in other populations.
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