Modification of Short Non‐Permeable Peptides to Increase Cellular Uptake and Cytostatic Activity of Their Conjugates

In this work, we describe the synthesis and investigation of a variety of Dabcyl containing cell penetrating peptides. A variety of Dabcyl-containing analogues were prepared, to improve the cellular uptake of tetrarginines. We studied the number and location of Trp within the sequence, and we noticed that the presence of Trp in our sequences can enhance the uptake of the peptides, especially if it is placed at the N-terminus, adjacent to Dabcyl.