Pharmacokinetics and bioavailability of docetaxel-loaded lecithin nanoparticles in rats

Objective To study the pharmacokinetics and bioavailability of docetaxel-loaded lecithin nanoparticles in rats.Methods Marketed docetaxel injections were intravenously administered to rats at a dose of 20 μg/g.Docetaxel solution or docetaxel-loaded lecithin nanoparticles was administered orally at a single dose of 20 μg/g.HPLC method was applied to determine the plasma concentration of docetaxel.Pharmacokinetics and bioavailability of docetaxel-loaded lecithin nanoparticles were investigated in rats after oral administration.Results After single oral administration of docetaxel-loaded lecithin nanoparticles,the calculated Cmax was(116.19±28.58) pg/L,tmax was 1 h,MRT was(5.60±0.34) h and AUC was(490.74±37.28) h·pg·L-1.The oral bioavailability of docetaxel-loaded lecithin nanoparticles was 3.65 times of that of docetaxel solution.Conclusion The lecithin nanoparticles can significantly improve the oral bioavailability of docetaxel.