Clinical effects of Edaravone and early rehabilitation on acute cerebral infarction

Objective To evaluate efficacy of Edaravone and early rehabilitation on acute cerebral infarction(ACI).Methods Performed a randomized controlled study on ACI patients.68 patients,enrolled within 48 h of onset,were allocated to Edaravone group(n=34)and control group(n=34)randomly.Before and after treatment,the neurological deficits and activities of daily living(ADL)were assessed using national institute of health stroke scale(NIHSS)and Barthel Index respectively.Clinical efficacy was evaluated according to changes of NIHSS and ADL scores between two groups on the 21th day.Results There was a significant difference of NIHSS scores between Edaravone group and the control group(P 0.05)on the 21th day.There was also a significant difference of ADL scores between Edaravone group and the control group(P 0.01).No distinct adverse reaction was observed in Edaravone group.Conclusion Edaravone combining with early rehabilitation therapy is an effective method of improving the neurological function impairment of acute cerebral infarction patients,being worthy of further evaluation.