The effect of liguistrazine on the expression of brain tissue FOS protein in neonatal rats hypoxia ischemia damage.

Objective To investigate the effect of the liguistrazine on the expression of brain tissue FOS protein in neuonatal rats hypoxia ischemia damage.Methods The hypoxia ischemia brain damage models were established by occluding the left common carotid artery of 7 day neonatal rats.The expression of FOS protein was assessed by immunostaining method.Results The expression of FOS protein was increased obviously in the ligated side of brain tissue( P 0.05).The liguistazine can suppressed the expression of FOS protein significantly compared with the control group( P 0.05).Conclusion The liguistrazine can refrain the expression of FOS protein in brain tissue. These datas suggest that the liguistrazine has neuroprotective effect on hypoxia ischemia brain damage.