To study the feasible for the discarded brewer's yeast adsorption heavy metal ions,on the basis of single factor experiment,use response surface method to make sure the best conditions for discarded brewer's yeast adsorption heavy metal ions.Result : the optimal adsorption conditions of metal ions by discarded brewer's yeast were : pH value is 3.15,adsorption temperature is 30℃,adsorption time is 60min,the density of discarded brewer's yeast is 2.04g/L and the density of metal ionsis 61.34mg/L.Under the above conditions,the adsorption rate of metal ions by discarded brewer's yeast can approximately reach to 62.78%.