Research progress of autophagy in modulating drug resistant of human tumors

Malignant tumors resist chemotherapy drugs through a variety of mechanisms.As a general physiological mechanism under both physiological and pathological conditions,autophagy can not only take part in maintaining homeostasis,but also be closely related with tumor development and resistant.Autophagy can be induced by chemotherapy agents through several ways in cancer cells,such as inhibiting PI3K-Akt-mTOR pathway,activating AMPK-mTOR pathway and inducing dissociation of Beclin1/Bcl-2 complex,which exerts an effect on the chemosensitivity.Therefore,autophagy is a potential target for antitumor drug resistant.Specific inhibition of autophagy in cancer cells combined with chemotherapy is expected to be an effective cancer treatment strategy.