In this paper, it studies dosage of composite inorganic salts catalyst, ethanol dosage and response time, with admixture of select catalytic synthesis of ethyl acetate and other factors on the yield effects under conditions of water combined with Composite Inorganic salts catalyst, ethanol and acetic acid by high-yield synthesis of ethyl acetate. Experimental results demonstrate that Ester yields was upto 87.57% for the best conditions, when ethanol:acetic acid mole ratio of 1.6:1 and Composite Inorganic salts is n(Fe2(SO4)3):n(K2SO4)=4.2:1, 14 m L reaction returning water, reaction time 110 min.