Studies on Antitussive and Antiasthmatic Action of Suhuangzhike Granules

Objective:To study the antiasthmatic,antitussive,and expectorant effects of Suhuangzhike granules.Method:Using the asthma model induced by acetylcholine and histamine mixture,antigen challenging(ovalbumin)and guinea pig' isolated trachea strip test the antiasthmatic effect was evaluated;using the cough model induced by ammonia,citric acid in mice,the antitussive effect was studied;phenol red test was used to observe the expectorant effect in mice.Result:Suhuangzhike granules could significantly prolong the latent period of twitch of guinea pig caused by acetylcholine and histamine,markedly decrease the number of leucocyte in perfusate of trachea and lung;and the degranulation rate of labrocyte in peritoneal fluid of guinea pig challenged by antigen,significantly decrease the tension of smooth muscle of trachea,significantly prolong the latent period of cough and decrease the frequency of cough induced by citric acid in guinea pig,significantly inhibit the cough induced by ammonia in mice,and increase phenol red excretion of trachea quantity in mice.Conclusion:Suhuangzhike granules has antitussive,antiasthmatic and expectorant actions.