Objective To observe the safety and reliability of lornoxicam combined with propofol in painless gastroscopy for patients complicafed with silicosis.Methods The 249 patients complicafed with silicosis were randomly divided into propofol group(group A),propofol +fentanyl group(group B),propofol + lornoxicam group(group C),with 83 patients in each group.The onset time of anesthesia,operation duration,anesthesia recovery time were recorded,and SBP,DBP,HR,SpO_2 before injection and 2min after injection were detected and observed,especially for the changes of SpO_2.The usage amount of propofol,the effect of anesthesia and analgesia during operation,intraoperative awareness degree and satisfaction degree for the effect of anesthesia were recorded and analyzed.Results There were significant differences in the onset time of anesthesia,anesthesia recovery time and usage amount of propofol between group B,group C and group A(P0.05),so were between group B and group C(P0.05).There were significant differences in the changes of SBP,DBP,HR before injection and 2min after injection in group A(P0.01),so were in group B(P0.05) and group C(P0.05).There was a significant difference in the change of SpO_2 before injection and 2min after injection in group A(P0.05),so were in group B(P0.01) and group C(P0.05).There were significant differences in the cases of excellent effect of anesthesia and analgesia,the cases of well satisfactory degree after operation and cases of intraoperative awareness between group B,group C and group A(P0.05),so were between group B and group C(P0.05).Conclusion Lornoxicam combined with propofol is safe and reliable in carrying out painless gastroscopy for patients complicafed with silicosis.