Chemical constituents in leaves of Ilex ficoidea

Objective To investigate the chemical constituents in leaves of Ilex ficoidea.Methods The various chromatographic techniques were used to isolate and purify the compounds and their structures were identified by the spectral data and physicochemical properties.Results Sixteen compounds were isolated from 95% ethanol extract and identified as friedelan-3-one(1),4-epifriedelin(2),lupeol(3),oleanolic acid(4),3-acetoxy-oleanoic acid(5),3β-acetoxy-6α,13β-dihydroxyolean-7-one(6),2-(4-hydroxybenzyl) malic acid(7),quercetin-3-O-α-L-arabinopyranoside(8),hyperoside(9),cis-syringin(10),ethyl-O-β-L-arabinopyranoside(11),emodin(12),chrysophanol(13),physcion(14),α-spinasterol(15),and β-sitosterol(16).Conclusion All the compounds are isolated from the species for the first time,among which compounds 1,2,6—8,12,and 13 are isolated from the plants in genus Ilex L.for the first time.