医学
异烟肼
肺结核
养生
药品
药理学
内科学
儿科
病理
作者
Vidya Mave,Ajay Chandanwale,Aarti Kinikar,Sandhya Khadse,Anju Kagal,Nikhil Gupte,Nishi Suryavanshi,Smita Nimkar,Hari Koli,Sultanat Khwaja,Renu Bharadwaj,Samir Joshi,Howard Horng,Leslie Z. Benet,Geetha Ramachandran,Kelly E. Dooley,Amita Gupta,Monica Gandhi
出处
期刊:International Journal of Tuberculosis and Lung Disease
[International Union Against Tuberculosis and Lung Disease]
日期:2016-06-01
卷期号:20 (6): 844-847
被引量:8
标识
DOI:10.5588/ijtld.15.0882
摘要
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.
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