Periosteal Osteogenesis in Mandibular Reconstruction:a Study in Miniature Pigs

Objective:To clarify the feasibility of periosteal osteogenesis in situ to repair the mandibular segmental defect.Methods:The premolars and molars in the right mandible of eight 13-month old minipigs were extracted.Three months later,the animals were randomly divided into two groups(A and B),four animals in each group.In group A,30mm and 40mm bone segments were removed from the right mandible,and neighbouring periosteum was preserved.In group B, 30mm and 40mm bone segments were removed from the right mandible,and the periosteum was removed stimultaneonsly. The defects in both groups were retained and further reconstructed by titanium plates.The mandibles reconstruction were checked by X-ray examinations at 4,8 and 12 weeks after operation.Results:At the end of 12 weeks,the regular new bones were formed in group A,which meant bone repair was finished.Slight irregular new bones formed in group B, which meant bone repair was not finished.Conclusion:Using periosteal in situ osteogenesis can repair the mandibular segmental defect.