In order to improve the filter press dewatering efficiency of waste mud,PAM was selected as flocculant. The influence of PAM with different kinds,different molecular weights( MW) and different doses on the filter press dewatering performance of drilling clay mud was studied by the physical-chemical method. The results was studied. The results showed that anionic PAM( APAM) flocculant improves the drilling clay mud dewatering performance. The optimal flocculant is APAM with MW of 10 MDa,and the influencing rule of different doses on the filter press dewatering performance of drilling clay mud was determined. On the basis of the above results the mathematical model of optimal PAM filter press dewatering flocculant was established,which provides some reference to guiding drilling waste mud clay processing.