Objective:To explore the relationship between the serum level change of adiponectin(ADP) and the infarction volume of patients with acute cerebral infarction.Methods:The serum level of ADP of patients in cerebral infarction group and control group was detected by ELISA.The cerebral infarction group was divided into lacunar infarction group and cerebral infarction group.Results:The serum level of ADP was obvious lower in 48 hours after infarction in cerebral infarction group than control group,and was obvious negative relation with the infarction volume.The serum level of ADP was obvious higher in lacunar infarction group than cerebral infarction group.Conclusion:The serum level of ADP of patients with acute cerebral infarction decreases obviously in 48 hours after infarction and is negative relation with the infarction volume.The detection of serum ADP can help to diagnose the acute cerebral infarction early and judge the severity of patients' condition.