The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells

BACKGROUND AND AIM:To investigate the effect of cortex periplocae extract(CPE) on the differentiation of tumor cells K562 in vitro.MATERIALS AND METHODS:We examined the morphological changes of K562 cells after cultured with CPE;and investigated the induction effect of CPE on the production of Hb from K562 cells by using colorimetry.RESULTS:K562 cells morphology were destroyed by CPE.CPE also markedly reduced the production of Hb from K562 cells.CONCLUSION:CPE could kill K562 cells to some extent,but could not induce the differentiation of K562 cells.