Objective To investigate the clinical value of mechanical ventilation on the patients with acute severe organo phosphorus pesticide poisoning and respiratory failure.Methods From May 2003 to December 2010,a total of 92 cases with ASOPP and respiratory failure were analyzed retrospectively.In these cases,47 patients were treated with mechanical ventilation(group A) and 45 patients were not treated with mechanical ventilation(group B).The length of hospitalization and curative effect were compared.Results The length of hospitalization was significant shorter and the curative effect was more apparent in the group A than those in the group B(P0.01).Conclusion Mechanical ventilation is an important method to treat ASOPP with respiratory failure.It can remarkably increase the incidence of clinical healing and shorten the length of hospitalization.