The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction

Background: The cornea is transparent tissue that serves as the window of the eye, allowing light to enter from the outer environment. The corneal endothelium maintains corneal transparency; thus, its dysfunction results in corneal haziness and causes severe vision loss. The only available therapeutic choice for treating corneal endothelial dysfunction has been transplantation using donor corneas; consequently, researchers have been pressed to develop new therapeutic options. Keywords: Cornea, Rho kinase, corneal endothelial dysfunction, fuchs endothelial corneal dystrophy.