黑色素瘤
癌症研究
体内
体外
Wnt信号通路
转移
剜除术
医学
连环素
癌症
化学
生物
内科学
细胞生物学
生物化学
信号转导
外科
遗传学
作者
Yun Wang,Maoxing Liu,Yanli Jin,Sheng Jiang,Jingxuan Pan
标识
DOI:10.1016/j.canlet.2017.04.028
摘要
Uveal melanoma (UM) is the most common intraocular malignant neoplasm in adults. Despite the availability of enucleation, radiation and chemotherapy, the prognosis of patients with metastasis remains poor. Therefore, novel effective therapies for patients with metastatic UM are urgently needed. In the present study, we demonstrated that JSL-1, a novel HDAC inhibitor, effectively inhibited the proliferation. JSL-1 induced apoptosis with increased expression of proapoptotic BH3-only protein BIM in UM cells. JSL-1 suppressed migration and invasion of UM cells with MMP-2 decreased. Furthermore, JSL-1 blocked the canonical Wnt/β-catenin pathway, impaired self-renewal capacity and decreased percentage of ALDH+ cells, thereby reflecting elimination of UM cancer stem-like cells (CSCs) which are believed seeds of metastasis. Importantly, JSL-1 potently inhibited the growth of uveal melanoma xenograft in NOD-SCID mice. These results suggested that JSL-1 may be a promising therapeutic agent for UM.
科研通智能强力驱动
Strongly Powered by AbleSci AI