High-Level Ferulic Acid Production in Engineered Yeast Enables Discovery and Biosynthetic Application of Novel Enzymes from Piper nigrum

were identified and applied to the biosynthesis of 11-methoxy-bisnoryangonin and feruloyl-piperidine. Our work establishes a high-yielding yeast chassis for FA-derived natural products and expands the enzymatic toolbox for plant metabolite diversification.