Comment on “Effect of serum uric acid and gout on the incidence of colorectal cancer: a meta-analysis”

A meta-analysis conducted by Dr. Liu and colleagues disclosed that a higher level of serum uric acid correlated with a higher risk of colorectal cancer (relative risk = 1.35, 95% confidence interval = 1.27-1.43).1 The authors have introduced some possible mechanisms underlying this association. Some points deserve discussion.