细胞生物学
激酶
蛋白激酶A
细胞
生物
生物化学
作者
Xu Hu,Yong Liang,Xianxian Gao,Y. Eugene Chen,Yixuan Wang,F Wang,Xin Hou
标识
DOI:10.1016/j.bcp.2024.116204
摘要
Calcium/calmodulin-dependent protein kinase IV (CaMK4) is a versatile serine/threonine kinase involved in various cellular functions. It regulates T-cell differentiation, podocyte function, tumor cell proliferation/apoptosis, β cell mass, and insulin sensitivity. However, the underlying molecular mechanisms are complex and remain incompletely understood. The aims of this review are to highlight the latest advances in the regulatory mechanisms of CaMK4 underlying T-cell imbalance and parenchymal cell mass in multiple diseases. The structural motifs and activation of CaMK4, as well as the potential role of CaMK4 as a novel therapeutic target are also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI